Dr. Madhureeta Achari, MD

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[2]

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[3]

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Overview

Practice

About

FAQ

Accepts new patients

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Specialties

Neurology

LocationHouston, TX

Bio:

With over 20 years of experience, this compassionate neurologist excel...

Experience:

20+ years

Languages Spoken:

English

[15]

Common Treatments:

Migraine

Chronic Pain

Mild Concussion

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Institutes Attended:

MMU,

UT Health Houston,

Certificates:

MD,

Intern,

Res

[15]

NPI/License number:

1588689442

Hospital Affiliations:

Oakbend Medical Center

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AZ Awards:

Sex:

female

This is an AZ search result. This provider is not affiliated, endorsing or endorsed by AZcare, Please verify key information.

Sources:

[1]

Aetnawww.aetna.com

[2]

Bcbswww.bcbs.com

[3]

Bcbsmwww.bcbsm.com

Common Treatments:

Migraine

Chronic Pain

Mild Concussion

Dizziness

Epilepsy

Multiple Sclerosis

Parkinson's Disease

Stroke

Insomnia

Sleep Apnea

Tension Headache

See More

Institutes Attended:

MMU,

UT Health Houston,

Certificates:

MD,

Intern,

Res

[15]

NPI/License number:

1588689442

Hospital Affiliations:

Oakbend Medical Center

See More

AZ Awards:

Sex:

female

Overview

Dr. Madhureeta Achari is a board-certified neurologist and psychiatrist with over 20 years of experience, dedicated to providing comprehensive and compassionate care. She possesses unique expertise in neurology, psychiatry, headache disorders, and neuroimaging. Dr....

Practice

In-network insurance

[3][...]

Aetna

Blue Cross Blue Shield

Blue Cross Blue Shield of Michigan

Cigna

Curative

First Health

Insurance info is for reference only. Contact the provider to confirm they accept your plan, as some may decline certain insurances even if technically in-network.

Appointments Scheduling

Memorial Hermann Memorial City Medical Center

In-Person Visit

Address:

1411 Heights Blvd, Houston, TX 77008

Phone:

(832) 793-7530

Fax:

(832) 793-7540

About

NPI/License number:

1588689442

[13]

Experience:

20+ years

Languages Spoken:

English

[15]

Hospital Affiliations:

[15]

Oakbend Medical Center

Texas Heart Institute

Memorial Hermann Memorial City Medical Center

Specialties:

Neurology

Psychiatry

Headache

Neuroimaging

Common Treatments:

Migraine

See More

Education & Certifications:

Residency in Neurology

University of Texas Health Science Center at Houston1996

Internship in Internal Medicine

University of Texas Health Science Center at Houston1993

Doctor of Medicine

Mcgovern Medical School at Uthealth1992

Bachelor of Science in Biochemistry

Rice University

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Publications:

Clinical Features and ATTCT Repeat Expansion in Spinocerebellar Ataxia Type 10

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder characterized primarily by progressive ataxia and seizure disorders, caused by a large expansion of unstable ATTCT pentanucleotide repeats in the SCA10 gene on chromosome 22. This study investigated the clinical features and genotype-phenotype correlations in two large Mexican American families affected by SCA10, involving 22 individuals. Ataxia was the initial symptom in 21 patients, while seizures developed in about half, with significant variation between families: only 25% of affected individuals in family 1 had seizures compared to 80% in family 2 (p = 0.01). Brain imaging consistently showed cerebellar atrophy, and EEGs revealed epileptiform discharges in half of those studied. The study observed genetic anticipation—earlier disease onset in successive generations—more strongly in family 1, where paternal transmissions were associated with an average increase of ~1940 ATTCT repeats. In contrast, family 2 showed repeat contractions despite anticipation. The seizure phenotype and repeat expansion patterns were family-dependent, suggesting additional genetic or environmental modifiers influence disease expression. Clinical complications included seizure-related morbidity and mortality, as exemplified by a patient who died from status epilepticus. This work establishes seizures as an integral part of SCA10, with complex genotype-phenotype relationships influenced by repeat expansion dynamics and family background. Future research is needed to clarify the pathogenic mechanisms of the ATTCT expansion and to explore therapeutic approaches.

By Raji P. Grewal + 7 more

01-08-2002

Clinical Features and ATTCT Repeat Expansion in Spinocerebellar Ataxia Type 10

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder marked by progressive cerebellar ataxia and seizure disorders, caused by a large expansion of an unstable pentanucleotide ATTCT repeat in the SCA10 gene on chromosome 22. This study examined 22 affected individuals from two large Mexican American families, revealing that ataxia was the initial symptom in nearly all cases, with seizures developing later in about half of the patients. The frequency and type of seizures differed significantly between families: only 25% of affected individuals in family 1 had seizures, whereas 80% in family 2 experienced seizures, mostly generalized motor seizures with some complex partial seizures. MRI and CT scans consistently showed cerebellar atrophy, and EEGs detected epileptiform discharges in many patients. Genetic analysis highlighted anticipation—earlier onset in successive generations—but the correlation between repeat size and age of onset varied between families, with paternal transmissions in family 1 often increasing repeat size and family 2 showing repeat contractions. Patients in family 1 also exhibited subtle personality changes and apathy. The findings suggest that seizures are an integral, yet variable, component of SCA10 phenotype and that family-specific factors influence clinical expression and repeat instability. The study underscores the complexity of genotype-phenotype relationships in SCA10 and points toward the need for further research on the mutation’s pathogenic mechanisms.

By Raji P. Grewal + 7 more

01-08-2002

Mapping of the gene for a novel spinocerebellar ataxia with pure cerebellar signs and epilepsy.

This study reports the identification and genetic mapping of a novel autosomal dominant spinocerebellar ataxia (ADCA) characterized by pure cerebellar ataxia combined with generalized epilepsy, a clinical combination not previously described in ADCAs. Researchers examined a large four-generation Hispanic family of Mexican origin presenting with progressive cerebellar ataxia and seizures. Genetic testing excluded known SCA loci with CAG repeat expansions (SCA1, 2, 3, 6, and 7) and excluded SCA4 and SCA5 by linkage analysis. Genome-wide linkage screening localized the disease locus to an 8.8 cM region on chromosome 22q13-qter, flanked by markers D22S1177 and D22S1160, with a maximum LOD score of 3.86 at marker D22S274. Clinically, 12 individuals were affected, with 67% experiencing generalized motor seizures starting between the third and fifth decades of life. Onset of ataxia symptoms averaged 36 years, with anticipation observed across generations. Neurological exams revealed typical cerebellar signs such as gait and limb ataxia, dysarthria, gaze nystagmus, hypotonia, and impaired smooth pursuit, without spasticity. This discovery extends the spectrum of ADCAs, linking a novel clinical phenotype to a specific chromosome 22 locus and paving the way for gene identification.

By Tohru Matsuura + 5 more

01-03-1999

Somatic and Germline Instability of the ATTCT Repeat in Spinocerebellar Ataxia Type 10

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurodegenerative disorder marked by ataxia, seizures, and genetic anticipation, caused by a large expansion of an ATTCT pentanucleotide repeat in intron 9 of a novel gene (SCA10) on chromosome 22q13.3. This study analyzed multiple families and demonstrated that the expanded ATTCT repeat is one of the largest microsatellite expansions known to cause human disease, exhibiting marked instability particularly during paternal transmission, while maternal transmission showed significantly less repeat size change. The repeat displays somatic and germline mosaicism in diverse tissues including blood leukocytes, lymphoblastoid cells, buccal cells, and sperm. Unlike other repeat disorders, the expanded ATTCT repeat length remained stable within individuals over a 5-year follow-up period, and clinical anticipation was sometimes linked to intergenerational repeat contraction rather than expansion. The findings highlight the complex dynamics of repeat instability in SCA10, distinct from other autosomal dominant cerebellar ataxias caused by CAG trinucleotide expansions, providing new insight into the mechanisms of repeat expansion diseases and their variable clinical presentations.

By Tohru Matsuura + 13 more

01-06-2004

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Aggregated Ratings: 4.7

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FAQ

Dr. Achari specializes in Neurology, Psychiatry, Headache, and Neuroimaging.

She treats migraines, epilepsy, Parkinson's disease, multiple sclerosis, stroke, neuropathy, sleep apnea, dementia, and Alzheimer's disease.

She performs EEG (electroencephalogram) and sleep and EEG testing.

Yes, she has expertise in diagnosing and managing all types of headaches, including migraines and tension headaches.

Yes, she provides care for Parkinson's disease and other movement disorders.

Her office is at 1411 Heights Blvd, Houston, TX 77008, and she is affiliated with Memorial Hermann Memorial City Medical Center.

She earned her MD from McGovern Medical School at UTHealth (1992), completed her neurology residency at University of Texas Health Science Center at Houston (1996), and is board certified in Neurology.

She speaks English.

She accepts Aetna, Blue Cross Blue Shield, Cigna, Curative, First Health, Humana, MultiPlan, and UnitedHealthcare.

Patients praise her compassion, expertise, and thoroughness, with an average rating of 4.71 out of 5 from 144 reviews.

Common Questions

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